Invega (paliperidone)

Invega (paliperidone)

Brand name: Invega®.
Active ingredient name: Paliperidone.
Type of medication: Atypical antipsychotic.
Available in Canada from: Janssen Inc.
Form: Oral tablets.
Generic: No.
Listed on Ontario formulary: Yes.
OHIP+ coverage: Yes.
Note: Invega® is also available as  long-acting injectables called Invega® Sustenna® and Invega Trinza®.
What is Invega used for?
Invega is used to treat the symptoms of schizophrenia and related psychotic illnesses in adults. Your doctor may prescribe Invega for other conditions. Discuss with your doctor the reason you are taking Invega.

How should I take Invega?

Invega can be taken once daily with or without food. Invega is available in 3 mg, 6 mg, and 9 mg tablets. The usual dose range for Invega is 3 mg - 12 mg per day. Your doctor may prescribe doses higher than 12 mg based on your individual clinical situation. Discuss your dose with your doctor.

What are the most common side effects seen with Invega? 

The most common side effects of Invega include:

  • Headache
  • Feeling of restlessness (akathisia)
  • Abnormal movements (extrapyramidal symptoms)
  • Insomnia
  • Dizziness
  • Nausea
  • Dry mouth
  • Constipation
  • Weight gain

What are rare but potentially serious side effects seen with Invega?

  • Decreased white blood cell count (agranulocytosis)
  • Cerebrovascular event (stroke)
  • Anaphylactic reaction (severe allergy)
  • Diabetic ketoacidosis (DKA)
  • Neuroleptic malignant syndrome (NMS)


Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Invega is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may, however, be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.

What medications interact with Invega?

Tell all your doctors, pharmacists and dentist that you are taking Invega. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription, and herbal and vitamin products. When the levels of a medication are increased or decreased in your bloodstream, this can affect the medication’s efficacy and safety.

The following types of medications may interact with Invega:

  • Certain medications for allergies (e.g., Benadryl [diphenhydramine])

  • Certain medications for sleep (e.g., lorazepam, zopiclone)

  • Certain medications for pain (e.g., fentanyl)

Avoid drinking alcohol or using illegal drugs while taking Invega.