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Modecate (fluphenazine)

Modecate (fluphenazine)

Brand name: Modecate.
Active ingredient name: Fluphenazine HCL.
Type of drug: Typical antipsychotic.
Available in Canada from: Apotex Inc.
Form: Oral tablets.
Generic: Yes.
Listed on Ontario formulary: Yes.
OHIP+ coverage: Fluphenazine oral.
  

What is Modecate used for?

Modecate is used to treat schizophrenia and other psychotic illnesses in adults. It may be used for other conditions such as tourette’s syndrome as well. Ask your doctor why you are being prescribed Modecate.

How Should I take Modecate?

Oral Modecate can be taken with or without food. It is usually taken divided doses 3-4 times per day, however it can be given once per day depending on individual preference.
The injectable form of Modecate is no longer available in most jurisdictions. 

Modecate is available in 1 mg, 2 mg, and 5 mg tablets.
The dosage range for oral Modecate for schizophrenia and other psychotic disorders is 2.5 mg - 10 mg per day.
Ask your doctor about your specific dose.

 

What are the most common side effects seen with Modecate? 

The most common side effects of Modecate include:
  • Abnormal movements (extrapyramidal symptoms)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in both men and women
  • Muscle spasm (dystonia)

What are rare but potentially serious adverse effects with Modecate?

  • Decrease in white blood cell count (agranulocytosis)
  • Neuroleptic malignant syndrome (NMS)
  • Sudden cardiac death (heart attack)
  • Torsades de pointes (serious heart arrhythmia)

Warnings/Precautions

Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Modecate is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may, however, be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.

What medications interact with Modecate?

Tell all your doctors, pharmacists and dentist that you are taking Modecate. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription, and herbal and vitamin products. 

The following types of medications may interact with Modecate:

  • Certain medications for allergies (e.g., Benadryl [diphenhydramine])
  • Certain medications for sleep (e.g., lorazepam, zopiclone)
  • Certain medications for pain (e.g., fentanyl)
  • Anti-Parkinson agents
Avoid drinking alcohol or using illegal drugs while taking Modecate.