Neuleptil (periciazine)

Neuleptil (periciazine)

Brand name: Neuleptil®.
Active ingredient name: Periciazine.
Type of medication: Typical antipsychotic.
Available in Canada from: Erfa Canada Inc.
Form: Oral capsules, oral drops.
Generic: No.
Listed on Ontario formulary: Yes.
OHIP+ coverage: Neuleptil brand covered.

What is Neuleptil used for?

Neuleptil is used to control symptoms of hostility, impulsiveness and aggressiveness when used with other medications in adults and children over 5 years old. It is also used to treat schizophrenia and other psychotic illnesses in adults.

How should I take Neuleptil?

  • Neuleptil is available in 5 mg, 10 mg and 20 mg tablets.
  • The starting dose for adults is usually 5 mg - 20 mg in the morning and 10 mg - 40 mg in the evening.
  • Older adults will start at 5 mg a day. Your doctor may increase your dose if needed, but not usually more than 30 mg a day. Some doses may go above 30 mg per day. Discuss your individual dose with your doctor.
  • Children 5 years and older usually take 2.5mg - 10 mg in the morning and 5 mg - 30 mg in the evening.

What are the most common side effects seen with Neuleptil? 

The most common side effects of Neuleptil include:
  • Abnormal movements (extrapyramidal symptoms)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in males and females
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Nausea
  • Headache
  • Weight changes
  • Blurred vision

What are rare but potentially serious adverse effects with Neuleptil?

  • Decrease in white blood cell count (agranulocytosis)
  • Neuroleptic malignant syndrome (NMS)
  • Sudden cardiac death (heart attack)
  • Torsades de pointes (serious heart arrhythmia)
  • Seizures

Warnings/Precautions

Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Neuleptil is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may, however, be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.

What medications interact with Neuleptil?

Tell all your doctors, pharmacists and dentist that you are taking Neuleptil. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription.

The following types of medications may interact with Neuleptil:

  • Certain medications for allergies (e.g., Benadryl [diphenhydramine])
  • Certain medications for sleep (e.g., lorazepam, zopiclone)
  • Certain medications for pain (e.g., fentanyl)
  • Anti-Parkinson agents
Avoid drinking alcohol or using illegal drugs while taking Neuleptil.