Nozinan (methotrimeprazine)

Nozinan (methotrimeprazine)

Brand name: Nozinan®.
Active ingredient name: Methotrimeprazine.
Type of medication: Typical antipsychotic.
Available in Canada from: Sanofi-Aventis Canada Inc. (brand name only). Generic available from AA Pharma Inc.
Form: Injection, oral tablets.
Generic: Yes: Methoprazine.
Listed on Ontario formulary: Yes (25mg/mL injection is a general benefit). Oral tablets are not covered.
OHIP+ coverage: Yes (25 mg/mL injection), No (oral tablets).

What is Nozinan used for?

Nozinan is used to treat symptoms of schizophrenia and other psychotic illnesses. It may also be used to treat bipolar disorder, or conditions associated with anxiety. Nozinan may be used to treat other conditions as well. Discuss with your doctor why you are using Nozinan.

How should I take Nozinan?

  • Nozinan can be taken with or without food. It can be taken once per day, however, it is most often given twice or three times daily.
  • Nozinan is available in injectable form in a 25 mg/mL concentration. The generic form of Nozinan is also available in 2 mg, 5 mg, 25 mg and 50 mg tablets.
  • The oral starting dose of Nozinan for schizophrenia and other psychotic illnesses is 50 mg - 75 mg per day. The dose is increased up to a maximum of 1000 mg per day depending on response. Discuss your individual dose with your doctor.

What are the most common side effects seen with Nozinan? 

The most common side effects of Nozinan include:
  • Abnormal movements (extrapyramidal symptoms)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in males and females
  • Drowsiness
  • Dry mouth
  • Nausea
  • Headache
  • Weight changes
  • Blurred vision

What are rare but potentially serious side effects seen with Nozinan?

  • Decreased white blood cell count (agranulocytosis)
  • Neuroleptic malignant syndrome (NMS)
  • Anaphylactic reaction (severe allergy)
  • Torsades de pointes (a serious heart arrhythmia)


Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Nozinan is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may, however, be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.

What medications interact with Nozinan?

Tell all your doctors, pharmacists and dentist that you are taking Nozinan. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription, and herbal and vitamin products.

The following types of medication may interact with Nozinan:

  • Certain medications for allergies (e.g., Benadryl [diphenhydramine])
  • Certain medications for sleep (e.g., lorazepam, zopiclone)
  • Certain medications for pain (e.g., fentanyl)
Avoid drinking alcohol or using illegal drugs while taking Nozinan.